My information came from PaulErik, who is the god of metal halide ballasts. He was one of the first to import Radium bulbs to the US. According to him, the only significant difference is that the S51 uses a lower starting voltage. This doesn't necessarily damage the bulb, but it COULD cause the bulb to have trouble firing up when it gets older. The way to remedy this is have the cord from the ballast to the bulb as short as feasible. I've only been running them on s51 for about 3 months, no problems at all. I fully expect to get 12-18 months out of these bulbs. I've noticed no color difference from an M80 (white with a blue hue). It will drive 250w DE bulbs like Phoenix to spec as well. I bought them new for $35 each.