Fair point. However, hypo is also much more difficult than cupramine to apply correctly. Any slight elevation in salinity will render the treatment ineffective (salinity must be maintained in the narrow range of 1.008-1.009) because otherwise crypt will be able to reproduce (hypo does not kill crypt but only stops it from reproducing). Cupramine, on the other hand, is very easy to apply because it has a very broad effective range of .2-.5 and thus is hard to misapply. As such, careful and frequent toping off is critical to hypo because a failure to do so will ofen result in treatment failure. Plus, hypo is a much longer treatment of 8-10 weeks where cupramine is only 3. I find that the often undersized and poorly filtered quarantine systems cause more stress to fish than chemicals do. As such, I would contend that cupramine is far less harsh on fish than hypo because it allows one to get a fish out of substandard quarantine facilities much sooner, thereby greatly reducing stresss. Also, hypo only cures ich and no other parasites so it has limited application. Finally, because PH is hard to maintain in hypo and the lengthy treatment frequent water changes are often required in hypo which exponentially increase the liklihood that the treatment will not succeed because inevitably salinity gets too high for a period when doing these water changes (only need a brief period of elevated salinity for hypo to fail). Conversely, cupramine can usually be applied without a single water change because of its short treatment duration, and once you reach your target copper level it is pretty much a "set it and forget it" operation.