I did it with and 80 gallon for a couple years along time ago. I had two canister filters, which I hated cause the maintainance is a pain. I cant lie, my tank did pretty well. If I were to attempt it, I would keep my load on the tank light, take it easy on feedings. My answer is yes, it can be done, but IMO its not ideal and you will probably regret it in the end. I highly recomend rethinking the "no skimmer" though.