Jeffrey,
I don't think the actual location matters from a functional perspective. The things you need to think about are:
1) aesthetics: Where is the tank going to be located in the room would indicate what is the best "looking" configuration
2) Maintenance: What location is easiest to reach for cleaning, retrieving wayward fish, working on the plumbing, etc.
3) Clearance: what type of rockscaping will be used inside the tank. Internal overflows unfortunately take up alot of space inside the tank...make sure the location you choose will not interfere with your inhabitants/rockscaping, etc.
4) Capacity: the more linear inches of overflow teeth, the more gallons-per-hour your overflow can handle. for instance, a single overflow in the middle of the tank will handle more flow than the same size overflow in a corner (the center overflow has 3 sides as opposed to only 2 sides for the corner) That is why there are usually overflows in both corners...to compensate for the lack of surface area/linear inches. Likewise, a center overflow will usually be "stretched" to be wider (not square shaped) to increase the linear inches
The capacity issue is probably the most important. Be certain that whatever configuration you choose has enough linear inches of overflow space to match your desired gph.
RC has a calculator to use for this purpose:
http://reefcentral.com/calc/drain.php
Simply enter how many GPH you wish to achieve and the calculator will tell you what the minimum pipe (drain) diameter is required AND the minimum linier inches of overflow teeth needed.
I hope this helps
Kevin