Heres my opinion.
1: your drain size is going to have to be sized to your return pump. What kind of drain are you doing? herbie, bean or single or double durso? I would probably bet that 1" drains would be plenty, unless you are using some crazy return pump. Plumbing a bean is kind of a gold standard these days, but if you don't have room a herbie will do in a pinch.
2: If you are drilling your returns as well, since its pretty hard to find 1" or bigger loc line, I would drill the same hole for the return as you would for the 1" bulkhead (if that's what you go with) and then you can use a 3/4" sch 80 bulkhead that will fit the 1" hole. Like this:
http://glass-holes.com/3-4-Thread-x-Thread-Bulkhead-Schedule-80-FT1143.htm
This way you wont have to buy a second bit to drill one lousy hole.
3: I like to use a general rule for plumbing the return pump of 1.5x the pump fittings. So if the pump is outfit with 1" fittings, then you would use 1.5" plumbing all the way up to your bulkhead, where it would be ok to reduce it to get into the tank since your locline is probably going to be 3/4" regardless.
4: make sure you place your holes at least 1.5x the distance of the last hole, or edge of the glass plate (even the top). This way there is enough material to maintain the integrity of the glass between the holes. Otherwise it could/would crack.
5: make sure you terminate the ends of your return nozzles as near the surface as you can get them (can be accomplished with a length of locline.) This way when the power goes out, there wont be much water back siphoned to the sump and it wont over flow.
6: Use a gate valve on the siphon line, not a ball valve. and place the gate valve as close to the sump as possible.
7: On both the siphon line and the return lines, keep the elbows, fittings and horizontal runs to a minimum. On the siphon line it will cause it to have problems restarting the siphon by trapping air in the system, and on the return line it will severely kill your pump output. My suggestion is to use flex PVC as much as possible where you need some turns instead of using elbows or 45s. The more gradual the better.
8: Though Ive done it for years without issue, no one recommends anymore using PTFE tape (Teflon tape) on PVC pipe threads, your supposed to use pvc specific paste to seal the joints.
grab a beer, sit down and watch these, they explain things pretty well.
https://www.youtube.com/watch?v=q1tAnhIGpgA
https://www.youtube.com/watch?v=U9OCuUFg_lk
https://www.youtube.com/watch?v=wVFZtmXX6ck
https://www.youtube.com/watch?v=aaDDKNA4cn0