kjonulak
New member
You dose 20mg's of Fluconazole/gallon. You would need 2,000 mgs. If you get the 250mg capsules, you would need 8 of them.
Fluconazole - Bryopsis Killer
- Thread starter kjonulak
- Start date
You dose 20mg's of Fluconazole/gallon. You would need 2,000 mgs. If you get the 250mg capsules, you would need 8 of them.
RobZilla04
Active member
Any pics? I'd like to follow along and I'm sure others will as well.
RivieraBayReef
New member
I just dosed 5000mg in my system about 4 days ago. Nothing extremely noticeable yet. I'll let everyone know how it goes.
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Hello guys
My name is Jose Mayo, MD, I live in Brazil and I am part of ReefClub, a good Brazilian site for marine aquarism. It was mine, in 2014, the first account of fluconazole's action on problematic marine algae, especially bryopsis and derbesia, which infested my marine tank. I also carried out the first research on the mechanism of action of fluconazole in these algae and developed the first protocols of treatments that proved to be effective. Since then I have sought to disseminate these observations as much as possible, for the pleasure of watching many aquarist colleagues solve their problems with difficult algae. Sincerely congratulations for the excellent work of disseminating your results on the use of fluconazole in the control of bryopsis and green hair algae; simply amazing!
Keep up the good work!
Thank you all!
My name is Jose Mayo, MD, I live in Brazil and I am part of ReefClub, a good Brazilian site for marine aquarism. It was mine, in 2014, the first account of fluconazole's action on problematic marine algae, especially bryopsis and derbesia, which infested my marine tank. I also carried out the first research on the mechanism of action of fluconazole in these algae and developed the first protocols of treatments that proved to be effective. Since then I have sought to disseminate these observations as much as possible, for the pleasure of watching many aquarist colleagues solve their problems with difficult algae. Sincerely congratulations for the excellent work of disseminating your results on the use of fluconazole in the control of bryopsis and green hair algae; simply amazing!
Keep up the good work!
Thank you all!
Just ordered from payless-petproducts and it was shipped within 15 minutes! I've been battling GHA and Bryopsis for a while now and have it slowly dying off with aggressive cleaning, feeding sparingly, and lower my white light but I'm hoping fluco will be the final blow. I'll repost during treatment to show results.
I would like some for a back up if needed. I am treating 300 gallons in my classroom right now (today is day 1) How many do you have left?
The treatment is done with a single dose of 20 mg / gallon, having removed the skimmer cup (leaving the skimmer on without the cup, for aeration and pH stability), activated carbon and the like (so that they do not remove the medicine from the aquarium). The GFO can be maintained; Generally the time required for algae eradication is 14 days, counted from the day of the single dosage.
You can find fluconazole in any drugstore / drugstore for human medicines and / or veterinary medicines. Maybe in the UK you need a prescription, to get it.
Fluconazole works by blocking the ergosterol synthesis pathway, a structural lipid that makes up the cell walls of fungi in general and some GREEN and BROWN algae. By blocking this synthesis of ergosterol, fluconazole renders the wall of the algae brittle and permeable, and this succumbs to the aggressiveness of the environment in which it lives. In addition, fluconazole also alters the production of diterpenoids by algae, which are the allelochemicals with which they defend against herbivores, so it is not uncommon for algae to be attacked by snails, crustaceans and fish herbivores, who previously refused to eat them.
RED ALGAE has cholesterol on its walls, not ergosterol, so it's almost never affected. Some macroalgae, such as Caulerpa sp, Codium sp and Halimeda sp, may be affected by fluconazole at high dosages. Cladophoráceas, such as Cladophora sp, Cladophoropsis sp and Chaetomorpha sp are resistant, but not totally "immune" to fluconazole.
ATS beds should be removed during treatment and sterilized before returning to the system, as well as all equipment used in the aquarium and that can store algae spores, otherwise they will "return" after the treatment is finished and the effect of fluconazole ceases .
All animals, from protozoa to higher animals, have cholesterol in their cell membranes and do not synthesize ergosterol, so they are not affected by fluconazole even at high dosage. What can happen, and will run, if no precautions are taken, is that in aquaria where algae infestation is very advanced, and if these algae are toxic, the fauna may be affected by products released in the decomposition of these algae.
In highly affected aquaria, the largest quantities of algae should be manually removed first and then treated with fluconazole to completely eradicate them.
Regards
You just dose once
You can buy it here and the site also gives you a dosage calculator plus instructions
https://bryopsisfluconazole.com
You just dose once
You can buy it here and the site also gives you a dosage calculator plus instructions
https://bryopsisfluconazole.com
kjonulak
New member
I know I started this thread for Bryopsis, and the fluconazole works great. I recently had another algae run rampant in my tanks. Jose Mayo identified it as Caulerpa verticillata. It took 2 treatments of the fluconazole plus during the 2nd treatment of the fluconazole I also started an H2O2 2x daily treatment. Finally my tanks are free of the Caulerpa verticillata.
Evster
New member
I'm not sure if I did something wrong, but it's been a week now and I haven't noticed any die-off at all.
I've left my skimmer running but without the top. Filter socks are still in.
I do have quite a bit of algae going on atm.. so maybe I'll notice it during a second dose??
The instructions say to do the water change after 3 weeks, so I guess I'll try again then..
Should I be manually pulling stuff out as well?
I've left my skimmer running but without the top. Filter socks are still in.
I do have quite a bit of algae going on atm.. so maybe I'll notice it during a second dose??
The instructions say to do the water change after 3 weeks, so I guess I'll try again then..
Should I be manually pulling stuff out as well?
kjonulak
New member
What type of algae do you have? Bryopsis is the first to be affected, but the time can vary. Hair algae can take weeks and a 2nd treatment.
It is best to not manually remove it. It affects the algae from the tip to the root.
Fourstars
New member
Thank you so much for your work Jose! You helped make reef keeping enjoyable again. :beer:
