I only drive to Florida....geez, I hate to fly, and a Styrofoam container will drive you crazy squeaking for 22 hours. Spring for a good, hard plastic cooler and you'll be better off. I have transported many things back from Florida for over 10 years without any casualties. During very cold weather, I keep a lot of heat packs on hand to replace before things get cool. Keep a thermometer between a couple of the bags so you can get a temp reading. A piece of bubble wrap over the top of the bags with a blanket on top will keep all the heat from escaping when you open the cooler.
I am considering asking my son, a pilot, to see if he could bring things on board the next time he comes from Orlando...I just don't want to get him in trouble for trying!!