Depends on your goals. I have a 4x2x2, with a pair of MP40s and a pair of MP10s. They're dialed down a lot, but have great random flow throughout the tank.
I also paid for all of them what you'd pay for a single MP40QD, so there's that, too. Bargain hunt and shop around for good equipment, rather than sticking a half dozen ugly cheapo powerheads.