Hypo salinity

Yes, I have. I have treated 11 fish who had severe cases, and prophylax all new fish with it. No mortality from hyposalinity in the 2 years I have had my tank.

There are several key points that you have to make sure are followed, otherwise the treatment will end up in failure.
 
As newbie on this procedure did suffer one mortality, only two fish as nano cube, even perhaps other stress going on. Looks like Ich. Lost a fish on 4th day of procedure. Likely went too fast on salinity drop. Will say the honey Damsel left is incredibly hardy, my bicolor not as well. Will be more cautious on using this method in future, thanks all for the feedback.

I'm going to continue with a different method, was so disappointed with a fish loss raised the salinity quickly, Damsel didn't even blink, replaced the removed invertebrates as they will not have a chance at such a low salinity.
 
I've used both hyposalinity and cupramine successfully. To me, I prefer cupramine because of 3 things:
1.) I don't have to guess if it is velvet or ich.... copper treats both where as hypo only treats ich.
2.) My fish seem to tolerate it just as well as hypo.
3.) Hypo is very hard to get and keep the correct salinity level... You MUST have a perfectly calibrated refractometer and make sure to never let the salinity rise above 1.009 (an ATO greatly helps). In a bare bottom with cupramine, keeping the appropriate copper levels is much easier imo.

I failed once with a blue hippo tang in hypo and had to retreat with cupramine after (this is why people watch them in QT for at least 3-4 more weeks after treatment =) ). The blue hippo (and more importantly my entire tank) has been ich free for almost a year now!
 
I'm not certain that you can really lower salinity "too fast". I know that if the situation is bad, you can drop them into 1.009 salinity immediately. It's going back up that must be done slowly.
 
As newbie on this procedure did suffer one mortality, only two fish as nano cube, even perhaps other stress going on. Looks like Ich. Lost a fish on 4th day of procedure. Likely went too fast on salinity drop. Will say the honey Damsel left is incredibly hardy, my bicolor not as well. Will be more cautious on using this method in future, thanks all for the feedback.

I'm going to continue with a different method, was so disappointed with a fish loss raised the salinity quickly, Damsel didn't even blink, replaced the removed invertebrates as they will not have a chance at such a low salinity.

I'm not certain that you can really lower salinity "too fast". I know that if the situation is bad, you can drop them into 1.009 salinity immediately. It's going back up that must be done slowly.

Like he said, you can bring the salinity down rather quickly and be just fine. I doubt that that's what caused your mortality. I brought mine down from 1.026 to 1.009 in a 48 hour period. Bringing it back up quickly, on the other hand, can be deadly. Bringing it up from 1.009 to 1.026 typically takes me just over 7 days. You got lucky with your damsel surviving the quick rise.
 
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