What is the thickness of the bottom glass? What is the spacing between the three holes? What is the diameter of each hole?
Unless the tank was built by a rank amateur who had no idea what he was doing, you're probably safe.
Most glass tanks do not have tempered bottoms. That's something you're more likely to find on cheapy tanks by the common lower-priced volume tank builders. They temper the glass so that they can get by with thinner glass.
My 120-gal tank, with 1/2" (12mm) Starphire sides, had a 3/4" (19mm) glass bottom and it was not tempered. I had only two holes drilled in it, one for a 1.5" drain bulkhead and one for a 1" return bulkhead. There was a good 2" of glass between these two holes and they were not in the middle of the tank but rather in the far left side at the rear.