Antibiotic in food is generally far less effective than administration in water. I'd think that with predators that eat a lot in one feeding it may work better.
I have not tried maracyn 2 in show tank, but maracyn (erythromycin) does not outright kill most nitrification bacteria, although I don't know its effect on invertebrates in a reef tank. In a FO tank I have used it long time ago. There was detectable nitrite but little ammonia.
The same is true for kanamycein and Neomycin. These antibiotics depress nitrification but does not outright kill most nitrification bacteria.
One antibiotic that is deadly on nitrification bacteria is chloromycetin. It wipes out nitrification. This drug is not much available because it is known to be related to some blood problem for dogs and cats, but my old vet still let me have some. Chloro is often more effective than many other antibiotics, sadly.