Use all 4 for closed loop, keep them all 3/4 inside the tank. I would run all 1in plumbing underneath from your closed loop pump up to where they come in and then just reduce on the 2 3/4 and glue straight in, then on the 2 1in do the same except no reducing needed. Use Slip x Threaded bulkheads, the threads being on the inside of the bulkhead end that will be in the tank. On the two that are 3/4 use the threaded 3/4 lock line and thread it in and direct to where you want the flow. On the 1in cut outs use 1in bulkheads, slip x thread just like the 3/4s and then immediately inside the tank use a thread x thread 1in x 3/4 reducer to reduce them to 3/4 make sure its thread x thread as you want to thread in 3/4 lock line into this. Direct them where you want and call it a day......this is all very simple plumbing 101 and shouldn't take you more than an hour......