Unlike most forms of copper used to medicate in aquariums, Cupramine isn't very likely to precipitate out, so as long as you don't have any carbon, purigen, or scavenging resins anywhere in your filter you probably won't have to add any more than the directions tell you. Definitely test, but be aware that most tests won't detect the copper in Cupramine so you'll need the Seachem copper test kit.