Definately want ammonia/nitites to be zero b4 a water change. I've heard you can remove the bacteria that is converting these chemicals into less harmful nitrates which can be removed thru anaerobic bacteria that live in deep sand beds(4-5inches) and some people have said that they have large pieces of live rock that don't get oxygen to their core and breed these bacteria and help with the denitrafication process. Also macroalgeas (caulerpa, cheatomorphea, etc) remove nitrates as well.