IMO, the secret to using copper is to introduce it gradually and increase slowly to the lowest therapeutic level (Most fish do well with Cupramine at about .35ppm.) I always make sure the fish is eating well before adding any copper, if he stops eating, that's usually the 1st sign to back off the copper. Red spots can occur too. If you go slowly and observe closely; you can usually avoid the severe symptoms described by AquaticFins above. Use only a Salifert (preferred) or Seachem copper test kit. I've had very good success with Cupramine using a slow method and always call their mfg, SeaChem with questions. They are great. (888-seachem I think.)
I know copper is controversial, I've use it on ever new fish for many years with excellent results. I think its almost impossible to find fish that haven't been treated with copper at some time. Collectors, shippers, wholesalers, online retailers, and many LFS use it routinely.