I have a few polyps that close more easily than others. They are my quick indicator. If I'm cleaning the glass more often, that's a clue too. The quality and amount of goo in the skimmer tells me a lot.
Small bubbles accumulating at the waters edge in both the DT and the sump is an indicater for me. While everything might look great, (corals/fish) it just means that the water is getting a little old, and the tank could use a small water change.
Pretty much anything that is different than the day or week before. If a coral is closed maybe a power head has moved maybe parasite. More algea check parameters. Fish not eating check everything. If its different there's usually a reason. Corals dont close because they feel like it.
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