I use multiple smaller heaters, I've had some fail, but the upside is when one fails it doesn't take everything out. I probably should connect them all to a temperature controller, but I guess I've just been lazy in setting up every bit with my tank, the ol "Hey it works I don't need to do anything else" mindset.
I thought about doing a PEX to water heater plan (if you have electric water heater, don't even bother, the math will beat you), researching it got the price very high in a short time, and then the other day my wife tells me there's no hot water, thermocouple crapped out on the burner, so there's a failure issue there (although I doubt it would have been catastrophic (from the time it died to when I fixed it 48-72 hours at most)... not having a fancy controller that sends me a text message that tells me something is wrong with my system has me leaning away from that direction.
Either way, if an electric aquarium heater craps out (and you're using more than one) it's not a critical failure and something that can be very quickly fixed because I have extras on hand (although knowing when one fails can be problematic), if my water heater failed, I'll take my time to fix/replace it I can go grungy for a couple days if necessary but don't want to think I need to hurry a solution because of my fish tank.