what plexi thickness for 6'x2'x4' tank?

Probably thicker than 1/2". Go through the acrylic fabrication thread, there answer is in there somewhere, and James has not been around lately to answer these questions. Maybe Floyd is taken it over...
 
what plexi thickness for 6'x2'x4' tank?
Would 1/4" be okay?

No...and actually 1/2" would not be enough, based on what you wrote... you're stating that the tank will be 4' tall ... Did you mean 2' tall (6'x4'x2') ?
 
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