I set up my most recent tank (a 90) in Nov of 2010. Started using BRS pellets on day 1. I'm running 500ml in an old modified Lifeguard fluidized sandbed canister I had laying around. It works remarkably well, actually. I went through the typical cycle, and at the end, my nitrates were ~30. In all my past tanks, I had to dilute this via water changes until a DSB or fuge or some other export mechanism came online. This time about 2 weeks after the cycle finished, nitrates were 0 and PO4 was at 0.03 according to the Hanna checker. That's where they have stayed, despite aggressive stocking and somewhat heavy feeding for the 4 anthias and other fish. Coral growth has been good, color is great, and there isn't a speck of algae. I did have the diatom looking slime for a while that some people have complained of, but they went away with no intervention on my part after about a month. No cyano or other issues. I'm not dosing any additional bactera, or aminos or anything else. So far, so good, and I feel like they are an essential part of my setup. I'll use them now, and on any other tanks I set up in the future.