Foxtrot Uniform Charlie Kilo!!!!
There goes my valida
Damn things.
Well here goes.... The big issue is what are these annulids most like-Trematodes, Cestodes or even Nematodes.
I think that biologically the AEFW's are most like the Platyhelminthese flatworms that comprise the Cestodes (tapeworms) and trematodes (flukes). Nematodes are classically roundworms causing intestinal and tissue disease in humans, and are likely not simular enough to the AEFW's. I think that we need to find a medication that will cover the disease of the flukes first. It would be nice to find a simular life cycle. With trematode infections there are both eggs and flukes in the body, so that treatment (if in high enough doses) may be the way to go. The only problem is that the egss are hosted by snails and the larvae infect humans.
Niclosamide or Praziquantel can treat Diphyllobothriasis.
In Diphyllobothriasis humans ingest larvae and pass the eggs. Prazipuantel will also treat Taenia saginata/solium, Clonorchiasis, paragonimiasis and the common (in my brain at least
) Schistosomiasis. Schistosomiasis the eggs induce granulomas. Praziquantel is used for all Trematode infections.
IMO, I think that Praziquantel would likely be the best to kill these damn things. The question is, what dose and what will happen to everything else? i haven't read anything on anyone useing this but maybe it is just a concentration issue.
According to Katzung praziquantel enhances Calcium influx and induces muscular contractions. THe drug increases the cell membrane permeability resulting in paralysis of the worm musculature. Vaculoization and disintegration of the tegment occur and parasite death follows."the drugs safety and effectiveness as a single oral dose have also made it useful in mass treatments...." In humans no major adverse effects have been described. In experimental animals, no effects are seen until doses approx 100 times the therapeutic range are reached; signs of CNS toxicity are then seen; A wide variety of mutagenicity, carcinogenicity, embryotoxicity and teratogenicity studies have been negative.
Given the therapeutic effect at 0.3 micrograms/ml I would shoot for this dose and see what happens. If everything looks good, but the FW's are still there I personally would double it redosing no sooner than four hours and then go from there. Again, I don't know of anyone else trying to use this and I am unaware of what does that they tried. It looks good with humans. You could do 50X the recommended therapeutic dose for human infections. Shoot for 15 micrograms/ml first.
What do you think?
