break them into 4 doses and wait 48 hours or more between to make sure the fish are still eating and doing well with the copper. The instructions for cupramine I think are 16 drops per 10.5 gallons wait 48 hours then redose. If you have a 10 gallon tank I would add 8 drops wait 48 hours make sure fish are eating then another 8 drips and so on........Make sure you have carbon and or cuprisorb just incase you need to remove the copper.