I have used NP's for 2 years now, in multiple configurations. I have run a high flow, a slow flow, used then in a canister filter with flow and no tumbling and the only difference to the ability to work has been the rate at which they dissolved. A high flow, like you get with the CadLights Bass-O-Matic reactor would cause enough friction of the pellets grinding against each other to make them dissolve much sooner. In my tank there was no difference in the ability to control nutrients in any of the several ways I have run them. They worked just as well in a canister filter as they did in a fast tumbling reactor, but they needed to be replaced more often. Friction is not really needed in the great amount that some reactors employ.
The RD reactor is one of the best designs available, a straight flow through is not very tunable, and the RD one is. That is the biggest difference. You can also control the tumble and this has it's advantages. You want bacteria to reside on the pellets and consume them, but with a high tumble you are sloughing off too much bacteria, as well as part of the pellet, friction works like that. I don't believe the small line diameter of the RD reactor is an issue but on a large tank it is possible that it could be.
IME you can use too many, they are very efficient at consuming NO3 and PO4. I was able to remove so many nutrients that my Chaeto died, the glass never had an algae coating and the SPS and LPS began to suffer. Start small and increase as needed. It has also been noticed that in some tanks a little liquid carbon source, VSV was helpful in getting them jump started. Everyone's tank is different, so don't rush it. They consume far more nitrates than phosphates so you may have to run GFO with them as well.