This is just one example so take it for what it is worth.
You guys have probably heard of Wiskey (James). He was a big fan of BB and of the BB fanatic (I use that in a good way

) that lives in Florida and works for NOAA. I forget his reefcentral ID.
Anyway, James tried BB. Did everything as prescribed by the BB thread: cooked rocks, bought a MR 3 skimmer with a Gen X 50, Tunzes for flow, better lighting, perfect RO water. But his SPS just wasn't doing well. After spending lots of money and time, he finally gave up.
He went to HD, bought a lot sand and now has a deep sand bed. SPS is doing much better.
I am beginning to think that there is something about having a sand bed but cleaning it every so often.
I have a DSB and SPS were going gang busters. Since I came back from Hawaii when the tank crashed, things are not doing so well. Maybe, time to replace the sand. I am way more careful now than back then with dosing, testing and everything.