After you do all of your research and learn what it takes and how much it costs, and you still think it's going to be fun, then I say go for it. For me, it felt like the next step for me in reef keeping. It's extremely challenging -- breeding fish that look like their wild counterparts is very hard -- but it's a goal I'm trying to achieve.
In terms of making a profit, as others mentioned, it's probably not going to happen. Everyone is breeding designers these days, so the price has come down significantly. One breeder in the local area can easily flood the market. Two breeders in the area, and you're giving clowns away.
With regards to cross-breeding, virtually every possible cross has been done, and those that aren't common are ones that shouldn't have been done. If you want to breed clowns, I suggest starting with a pure, wild strain and challenge yourself to make the babies look like their parents.