e55MD,
Sorry, I don't know of any formal studies, just anecdotal reports. We routinely maintain Coppersafe (similar to Cupramine?) in our quarantine systems, and sometimes, fish need to remain there through multiple 45 day cycles, we see no problems, but then, we also have not sent off any samples from deceased fish for histopath, at least not with the suspicion of copper toxicity.
My opinion is that these organically chelated copper products do not seem to cause chronic health issues. We used to see some peracute toxicity issues with Centropyge angelfish (and some other species) when we were using ionic copper at 0.22 ppm for only 14 days. We currently have a bicolor angel that has been in a Coppersafe system for months because it wasn't "playing well" with the soft corals in the tank it had been in.
Back in the mid-1980's, I ran a mortality rate study on 650 newly imported marine fish. the study ran six months, and the system had Coppersafe in it the entire time. None of the control fish (n=12) died during that run.
Jay