Not used Cupramine before as I normally use hypo when QTing new arrivals. Anyhow, directions say to dose 1ml then dose another 1ml 48 hours and leave for 2 weeks. During this time should I not change the water? Kind of worried about keeping water quality within acceptable levels without a WC for 2 weeks. Do must people do this twice and if so what is the dosage on weeks 3-4 (as there will be Cupramine in teh system still). Or maybe do a 75% water change and dose 2ml 48 hours apart again?