If it were mine, I'd do it. Id get a box-form of some sort [you can make it from slitted plastic,] section off about a 6x6 area, siphon that clean, add new sand, and then take out the box-form. I'd do that just next to that site on the 3rd day, and so on until I'd pretty well gotten the cc out of there and the new sand colonized by the bacteria. If you proceed slowly you can do it without provoking a cycle.