YOU can do that; you're not going to get much flexibility out of a 2 1/2 inch hose---or pipe. Stand by for some right angle turns because you'll be using pipe, and ABS will work for you---no pressure on the way down.
When you plumb the upline---put a union ball valve in the line so you can throttle back. I'd suggest an Iwaki 100 pump ---I use it on my 54 throttled down on a 15 foot run and 2 sea-swirls, with a 1" upline.
Note: my sump has two return ports, but I use one for the topoff, so everything comes down via the single 1 1/4 inch line, choked down from 1 1/2 at the bottom of the tank---I'm a bowfront, so I have only one downline. I ended up wanting no rigidity in my downline, so I used hot tub line, ribbed, and flexible as all getout. I hoisted it on macrame to prevent it hitting the floor, and it proves easy to manage, easy to cut.
Before you start, head for plumbing stores and get connectors that will work, because that was my biggest crisis: I had rock trying to go south on me, and couldn't find the right connectors. I ended up mating the original spa hose connectors from the tank to the new hose---which made the transit across the ceiling of the basement and into the laundry room really well without right angles.
That would be the main consideration in whether to use 2 separate hoses v 1 really big rigid pipe, is whether a slow curve will give you better flow.
HTH.