I have used Prazipro in my 210 gal tank when my Annularis angel had a nasty case of flukes. His eye was badly infected (all red, and bubbled-out). Two weeks after dosing, it was gone. No sign of flukes at all and his eye is perfect again.
I added it directly to my tank because my FO tank don't use live rock and I have no inverts. It says it is safe to use with live rock. I'm really not 100% sure.