Ca1ore makes a good point: absent experiments, we are left with people's experience using socks (or not) on as many different tanks as there are people. So what works for one person may not work for another since everyone has different tanks, coral, fish, flow, etc.. That being said, I think there are 2 opinions I have heard expressed that make some sense to me. First, if it makes no difference when you add socks then why bother using them. The second thought is watch how much gunk your socks catch; would you rather have that stuff in your tank?
Personally I have used 2 socks on my tank since I started it (just over a year, so still new), so can't say what it would be like without. What I do notice is the socks are dirty when I change them (once or twice a week depending how dirty), and I happen to have unreadable nitrates. So for me, I assume they do more good than harm. Then again I don't have any nps corals, or other mainly filter feeding corals.
So to specifically answer your concerns about socks, or not, or just one,... My 2cents would be try running them. If they are too much work, and/or if nitrates are climbing, try taking them out. Or do it the other way, try without and if you aren't satisfied with water clarity or you find too much detritus accumulating in the sump add socks. Big help, eh?
- Ian