I've actually dealt with alleopathy in my old 55 gallon reef. I had every type of nem in there and at one point hell broke out and my water was fouled up with an invisible slime that would clog my socks within hours, seriously hours. Although this is a possibility, my anemones seem to be doing great and eating well every week. 100 gallons should be fine for what I have for the time being. Once they start to outgrow the tank I'll consider a larger tank. I think this may be flow related but there is only one way to find out which is moving the anemone away from the pumps undertow. I'll let you know how it goes. I could always sell 1 mp40 and grab a gyre 150 and see how it goes. I really dislike cords in my tank and have a battery backup for my vortechs, although I'm aware Maxspect released a battery backup for the Gyre.
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