Usually there are some issues, Allelopathy (chem warfare) among different species, and not all nems have the same needs as far as flow and light, or substrate/rock.
Personally in a 45g I would only keep one host nem as most get big, or I would keep multiple of same species and only clowns as you won't have much swim space for other fish.
Sometimes different species play nice together but more often they don't.