Hyposalinity + Amoxicillin (or Cipro) + Chloroquine?

[ThRoewer]

My second Blue Spotted Jawfish came down with what looks like a bacterial infection:

It seems to have started from the tail which kind of speaks against velvet and brook (both of those start from the gills), so I'm fairly confident that this is bacterial.

I had it still in Hyposalinity (currently at 1.010 kg/L) from the suspected Ich and bacterial infection that killed the male.

Since I had treated the male's bacterial infection before with BiFuran I used this time Amoxicillin (Fish Mox) to avoid antibiotic resistance issues.
I started the treatment tonight .

In the morning I will get another BSJF I ordered over a week ago from BZ when the female looked fine. But the shipment didn't go out for last Saturday and is coming in today instead.

Just in case I want to be able to treat against velvet with Chloroquine Phosphate should that issue come up, but have no idea if that goes together with hyposalinity and Amoxicillin.

Anybody tried this before?

Also, if the Amoxicillin isn't working I may have to switch to Cipro - any contradictions with that and CP?

 

[snorvich]

Some reading for you

 

[ThRoewer]

While that thread contains some good info, it doesn't really help with my actual problem.

It is not Brook (or velvet) but clearly bacterial, or the fish would have died already.

Amoxicillin doesn't work, so I'm likely dealing with gram negative bacteria. So I ordered Kanamycin and will switch to that tomorrow.
I was considering Cipro, but unfortunately the Thomas Labs instructions are somewhat unclear:
"Directions: Pre-dissolve one tablet (500 mg) in two gallons of water prior to adding to a hospital tank. Immerse for one hour. Repeat every day for 5-7 days with daily water changes after each treatment."

Prior to adding what to the HT - the dissolved Cipro or the fish?
What is the dosage in the HT?

(BTW: I found a quite interesting series of threads about "BSJF disease" on Reef Sanctuary)

 

[tylersarah]

I've never been impressed with kanamycin, other abx seem to work better. What about Doxycycline? Works in a similar manner to Chloramphenicol - which is best for internal infection, I believe.

Also I'd kick the hypo, abx are more effective near 1.025

 

[Dmorty217]

While that thread contains some good info, it doesn't really help with my actual problem.

It is not Brook (or velvet) but clearly bacterial, or the fish would have died already.

Amoxicillin doesn't work, so I'm likely dealing with gram negative bacteria. So I ordered Kanamycin and will switch to that tomorrow.
I was considering Cipro, but unfortunately the Thomas Labs instructions are somewhat unclear:
"Directions: Pre-dissolve one tablet (500 mg) in two gallons of water prior to adding to a hospital tank. Immerse for one hour. Repeat every day for 5-7 days with daily water changes after each treatment."

Prior to adding what to the HT - the dissolved Cipro or the fish?
What is the dosage in the HT?

(BTW: I found a quite interesting series of threads about "BSJF disease" on Reef Sanctuary)

Dissolve the pill "prior" to adding the fish to the bath. Only dosage I know for Ciproflaxin is for anemones. I would start with 500mg per 10g and go from there. Would feed lightly and keep a eye on nitrites and ammonia. It's advised to do a 50-75% water change every 2-3 days when using antibiotics

 

[ThRoewer]

I go anemones to treat as well - if the fish wouldn't be in hypo I would just treat it with them together.

If I have enough left I may actually try Trimethoprim/sulfamethoxazole (Cotrim or Septra) with the fish as that seems to be even more broadband than Cipro.
I used Cotrim Forte in the past for sick percula and it worked well. I just forgot the dosage I was using back then.

In general hyposalinity should be vavorable to the effectiveness of antibiotics - it is close to the blood salinity they were developed to be most effective at. Higher salinities may reduce the effectiveness of many antibiotics.

 

[jbvdhp]

ThR - first off, wow, 4k posts in a little over a year! WOW!!

Anyway, just a thought here. Eyes are my profession and I just thought of something. For patients that come in with eye infections and dont have insurance, lets say, I usually prescribe something cheap like cipro, it covers both +/- bacteria, but I find that gentamycin works really well too, both generic. The fluoroquinolones work well and I like them, but the older gens like cipro or gati are the really affordable. Polytrim is an alternative as well.

I wouldn't know how to dose the drops for water, but I wonder if you could work for you? Try gentamycin?

 

[ThRoewer]

Where to get Gentamicin quickly and without prescription? Also, it may not be the right medication for a fish in hyposalinity (renal function issues).
I have Cipro at hand and might also still have enough Septra for one round of treatments (I hope).
After doing some reading I feel that Septra might be ideal since it also kills protozoan - just in case there is some brook in the mix too.

 

[ThRoewer]

Turns out I still have enough Septra 80/400.
I also found the dosage I used for the percula: one tablet (80/400) per 25 liter (~6.6 gal).

Doing water change right now to dose over night.
The fish is still hanging in and behaving fairly normal, also still eating.

 

[ThRoewer]

Gave the second dose - she isn't looking too good.

 

[ThRoewer]

Whatever this infection is, it seems Septra is killing it.
Last night the thick mucus she had on her fins was almost gone.