It's going to boil down to how much outside humidity you have (percentage and duration). I know it can get pretty humid in the northeast in the summer time. If those periods last longer than a few days, you will need to use something besides evaporative cooling to keep the tank temperature stable. During seasons where the outside humidity is pretty low, you can get away with fans for cooling and exchange with the outside.
450cfm doesn't sound like all that much to me. You (or a consultant, including some that will do it free for you) can do the thermodynamic calculation based on heat you're putting into the tank and the humidity and temperature deltas to determine what flow rate you'll need to evacuate the extra moisture. It goes up pretty significantly if you have a slightly higher humidity outside, so take care!
My tank room is about 16 x 18, I have 1000 system gallons, the outside humidity is never above 30% and often closer to 15 or 20%, and the temperature outside is always below my desired tank temp of 78F. With what are pretty much perfect conditions, I run two 450cfm fans (pointed one each way) and see duty cycles of about 50% during peak warm days.
One side problem I have is that the system doesn't know how to handle rain and snow. In those conditions, the "humidity" goes way up and the fans can get stuck in a feedback loop, bringing more and more water into the fish room. Since we don't get extensive rainy periods, it's never been a big issue.
Just seat of the pants, I would guess you could stay comfortably passive for at least 50% of the time. You'll probably still need the equipment to cool actively some subset of the remaining time, and then there'll be this middle ground where it'll work but have an aggressive duty cycle. It's certainly worth considering, if only for the electricity savings!
Good luck.