If you are familiar with the species, most of them don't look that much alike. Snails in the genus Nassarius almost all have circular apertures, a very short siphonal canal, and a parietal ridge on the columella at the top of the aperture (if the shell is held spire up) forming a pronounced anal sulcus. The circular appearance may be modified by the labral denticles, sulcus, and/or the columellar shield, but the actual apertures are very near circular, and the opercula are round or almost round as well. The opercula are usually thin, transparent amber discs or ovals. When the operculum is still attached to the animal, it usually appears to have a darker squarish or trapezoidal area in the middle, although most of the coloration is actually on the foot, rather than the operculum itself.
http://www.gastropods.com/Taxon_pages/TN_Family_NASSARIIDAE_NASSARIINAE.shtml
There are a few that don't totally conform to these standards. You might expect the ones with different-looking apertures not to be as closely related as the others, that their behavior might not be the same, and that some of them may very well belong in a genus other than Nassarius:
http://www.gastropods.com/5/Shell_29215.shtml
http://www.gastropods.com/0/Shell_3300.shtml
Some true buccinids look very much like Nassarius species, and in fact, some were once lumped together with them. These include the Nassaria species, which differ by having something of a siphonal canal, even if it's short:
http://www.gastropods.com/4/Shell_3194.shtml
http://www.gastropods.com/1/Shell_55771.shtml
http://www.gastropods.com/5/Shell_55775.shtml
The buccinids that look most like Nassarius are probably the Phos species. However, the apertures are generally rhomboidal rather than round, and the opercula are very different, conforming to the shape of the aperture, and most are dark and thick even though some are similar in color to those of the Nassarius species (opercula shown in several of the shells below):
http://www.gastropods.com/9/Shell_1279.shtml
http://www.gastropods.com/7/Shell_57097.shtml
http://www.gastropods.com/0/Shell_4770.shtml
http://www.gastropods.com/4/Shell_9704.shtml
On the bright side, I've never seen either a Nassaria or Phos species show up as a hitchhiker. The ones that seem to get confused over and over by aquarists are the Cantharus or Pollia species, or others in the buccinid subfamily Pisaniinae:
http://www.gastropods.com/Taxon_pages/TN_Family_BUCCINIDAE_PISANIINAE.shtml
These show up as hitchhikers all the time, and shouldn't be that hard to separate from the nassariids. Notice that they all have a distinct siphonal canal (or "stem"), that the opercula conform to the elongated shape of the aperture (teardrop shaped), and that most of the opercula are dark and thick, and very different from the usual Nassarius opercula.
Hope these hints help. They should be more dependable than "the snorkel is grey spotted" or whatever the other "rules of thumb" are that are proliferated around the hobby.
Cheers,
Don
P.S. My new rule of thumb for you: If it has a "stem" or siphonal canal, it's not a Nassarius.