I'll try. Bear with me as I set up the background for the discussion.
The nitrogen cycle is very important to our closed systems. When the organisms in our system excrete waste, it is largely in the form of ammonia. Ammonia is highly toxic to fish and even more so to invertebrates (Hence the need to "cycle" our tanks before loading them up with stock).
Fortunately, there is a naturally occuring bacteria that feeds on ammonia and produces nitrite as a byproduct. There is a second bacteria that feeds on the nitrite and produces nitrate as a byproduct. These two types of bacteria live on the surface of just about anything in an aquarium where oxygen is also present, including the glass, rock, coral and even fish.
That's where wet / dry filters come in. They are highly aerobic areas where there is a huge surface area for bacteria to cling too. That huge surface area is what makes them so effective in fish only systems that have a large bio-load (IE: Make lot's of ammonia).
The downside to this is that they don't take care of the nitrate. In a fish system, this is not a problem, since fish can generally handle large amounts of nitrate without problems. In most cases, periodic water changes will keep the nitrate levels in check without cause for alarm.
However, many of the organisms in a reef tank, notably clams and corals, do not tolerate high nitrate levels well, and will suffer, sometimes fataly in such an environment. For this reason, we need to take the process a step further to get deal with the nitrates.
Enter the partially-anaerobic zone. In order to deal with nitrates, you need a large area that is mostly anaerobic (Has very little oxygen). This would definitely not exist in a wet / dry filter as it is a near-perfect aerobic zone. LR and LS will provide a partially-anaerobic zone deep in the heart of the rock, or in the lower layers of the sandbed. This allows them to process the nitrates.
So, will a wet / dry work if you have LR and / or LS? Not efficiently. Because the wet / dry is producing the nitrate and putting it back into the water column, it is present immediately and has to somehow find it's way to the anaerobic zone to be processed. When the conversion to nitrate occurs very close to the anaerobic zone, such as on the surface of LR, it can be processed very efficiently by the nearby anaerobic zone, before it enters the water column.
So, in conclusion. What do you do? I'd simply remove the bio-media from your filter and add more LR or LS instead.
Did that make any sense?