Vitaly
Active member
In the context of the quote you posted, the author is specifically looking at the action of the toxin on sperm cells motility.<SUP>1</SUP> Totally different realm of chemistry for sperm and cardiomyocytes.
There are a number of published in vitro studies which I found in PubMed using your search criteria. Although, many of them do use caffeine (for its Calcium modulating effect), none indicate a reversal of the Palytoxin chemistry at the cellular level.
Moreover, most of the studies are using caffeine in the micro-milliMolar range. I cringe at actually calculating out how many cups of coffee or cans of Amp it would take to load the avg 70 kg hobbyists with caffeine in that range. Suffice it to use, it would not be possible.
Again, no doubt that the diuretic effects of caffeine may shorten the duration of symptoms, but my money is still on the emergency room for acute illness.
1) http://www2.hawaii.edu/~bemorton/Neuroscience/Neurochemistry/PalyMech.html
There are a number of published in vitro studies which I found in PubMed using your search criteria. Although, many of them do use caffeine (for its Calcium modulating effect), none indicate a reversal of the Palytoxin chemistry at the cellular level.
Moreover, most of the studies are using caffeine in the micro-milliMolar range. I cringe at actually calculating out how many cups of coffee or cans of Amp it would take to load the avg 70 kg hobbyists with caffeine in that range. Suffice it to use, it would not be possible.
Again, no doubt that the diuretic effects of caffeine may shorten the duration of symptoms, but my money is still on the emergency room for acute illness.
1) http://www2.hawaii.edu/~bemorton/Neuroscience/Neurochemistry/PalyMech.html
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