Here are a couple of interesting studies:
Hirazawa N., Oshima S., Hara T., Mitsuboshi T. and Hata K. 2001. Antiparasitic effect of medium-chain fatty acids against the ciliate <i>Cryptocaryon irritans</i> infestation in the red sea bream <i>Pagrus major</i>. <i>Aquaculture</i>.<b>198</b>:219-228.
Abstract:
The antiparasitic effect of short-chain (carbon numbers C<sub>2</sub> and C<sub>4</sub>) and medium-chain (carbon numbers C<sub>6</sub>ââ"šÂ¬Ã¢â‚¬Å“C<sub>10</sub>) fatty acids against the ciliate <i>Cryptocaryon irritans</i> was examined in in vitro trials. A challenge trial was conducted using the most effective fatty acid from in vitro trials to control <i>C. irritans</i> infestation on red sea bream <i>Pagrus major</i> at two temperatures (17°C and 24°C ). The in vitro results showed that C<sub>8</sub> (caprylic acid) had the strongest antiparasitic effect against <i>C. irritans</i> theronts. In challenge trials, uninfected fish were divided into six groups, 30 fish in each group three groups for each temperature , and fish were fed the same amount of experimental diet expanded pellet with different doses of caprylic acid at 0 control , 37.5 and 75 mg caprylic acid/kg B.W./day during the experiment, and then 2000 theronts were placed into each of the six tanks for 5 days after initiating the feeding of the experimental diets. Five fish of each group were randomly sampled periodically. The number of parasites on the gills and the eye surface in the treatment groups caprylic acid were significantly fewer than in the control group at 17°C. Mortality of fish did not occur in treatment groups during the trial, although all control fish died. At 24°C, mortality of fish occurred in all groups on the same day but the number of parasites on the gills and the eye surface in the group fed 75 mg caprylic acid/kg B.W./day was significantly fewer than in the control group. Our results indicate that caprylic acid has an antiparasitic effect against <i>C. irritans</i>.
Hirazawa N., Oshima S. and Hata K. 2001. In vitro assessment of the antiparasitic effect of caprylic acid against several fish parasites. <i>Aquaculture</i>.<b>200</b>:251-258.
Abstract:
The antiparasitic effect of caprylic acid against several fish parasites, i.e., the ciliate <i>Cryptocaryon irritans</i> (theronts), monogenean <i>Benedenia seriolae</i> (oncomiracidia and adults), copepod <i>Pseudocaligus fugu</i> (copepodids and adults) and myxosporean <i>Kudoa shiomitsui</i> spores , was examined by in vitro trials.
Caprylic acid at a concentration of 1 mM had a parasiticidal effect against <i>C. irritans</i> theronts, <i>B. seriolae</i> oncomiracidia and <i>K. shiomitsui</i> spores and a contractile effect against <i>B. seriolae</i> adults, but had no clear effect against <i>P. fugu</i> copepodids and adults. These results suggest that caprylic acid may have an antiparasitic effect against various fish parasites, including parasites classified as monogenea, ciliates and myxosporea.
They are interesting at two levels:
1) they demonstrate how one would go about studying the effectiveness of ginger on treating <i>C. irritans</i> infections. The second paper demonstrates the effectiveness of the tested compound directly on parasites and the first one studies the effectiveness of feeding the compound to infected fish.
2) If I am not mistaken, ginger (root) contains caprylic acid and it is possible that caprylic acid is the active ingredient. Both studies show that caprylic acid has some effects against <i>C. irritans</i> either in solution, or provided in the diet of infected fish.
For the moment, let's make the assumption that caprylic acid <b>IS</b> the active ingredient and the reason that ginger appears to be effective. The first study above showed that while fish fed with 75 mg caprylic acid/kg B.W./day had significantly fewer parasites, the treatment did not eliminate all the parasites and the fish still died 22 days after the challenge started (in the 24°C run). Two days after the initial challenge, the number of parasites on the gills of the fish over the three treatments (0 , 37.5, 75 mg caprylic acid/kg B.W./day) was not significantly different, although there were fewer parasites in the 75 mg treatment than 37.5 mg and fewer in 37.5 mg than 0 mg. At between 10 and 21 days there was a significant increase in the number of parasites on the gills and the eyes. In the case of the gills, the mean parasite count per fish went from 2.4 to 1,872, 1.0 to 1,386.8 and 0 to 656.4 in the control, 37.5 and 75 mg runs respectively. This indicates that the parasites went through at least one cycle, possibly two, despite the treatment.
It is likely that in an aquarium context, the fish are challenged by fewer parasites than in the study and so the treatment may reduce the parasites sufficiently to prevent death of the fish and also give the fish more time to acquire an immunity.
Seventy-five mg caprylic acid/kg B.W./day was more effective than 37.5 mg caprylic acid/kg B.W./day. If one was using ginger to provide the caprylic acid, how could you be sure than you have provided sufficient quantities? How much ginger do you need to feed the fish? It is possible that different ginger preparations include differing amounts of caprylic acid so even standardising on the amount of ginger may deliver different quantities of caprylic acid.
Even if caprylic acid isn't the (only) active ingredient of ginger, the same questions above still apply. How much ginger do you need to feed to ensure sufficient quantities of the active ingredient(s)? What about varying proportions of the active ingredient(s) between ginger preparations? While ginger may well work, it may be possible and easier to provide just the active ingredient(s) that the ginger itself.