The directions on my PP bottle recommended dosing Prime, AmQuel+, or a similar product with its use in an aquarium, anyway. I am wondering if, when treated in a display, they are preparing you for a possible ammonia spike from the additional worm types to the parasites that it will kill off. I used AmQuel+ with it in my display and did not seem to have a problem with efficacy, so I would assume that Prime is fine as well.
My Blue Throat Trigger didn't do too well with the PP, but he got over it in the first 24 hours of treatment.