jessp, remember that all of this is pretty much determined experimentally. When Randy Dorton discovered this treatment, he was searching for any medication that might work, and he tried different things. The published dosage is what he observed to be effective (and thought it was safe) for a 6 hour in-tank treatment. He also tested with stronger doses, even up to 100X, and found that it did not harm the coral. I don't believe 100X was ever tested in a display, and I don't think you should attempt to do that, either. The 100X is only if you are treating new corals in a bucket or holding tank.
I happen to use the lowest strength pills that are 1/10th as potent as the "large dog" pills. For me, it's more convenient since I treat in smaller containers. ~1/2 of a pill in a 5 gallon bucket works out to somewhere between 3X and 4X of the "normal" dose. With a bubbler and a heater, I leave the corals in the bucket for several hours, or even overnight.