It will work, i have done it before. The osmolator will fill to the lowest point of the wave, on a big tank it may be an issue but on a 75 or 90 it works perfectly. The main problem I found was that the wavebox wave action will knock some bubbles out of the skimmer and into the water column. The best would be if you could center the reefpack on the back wall since the water level doesn't change much in the center.