Let's all just calm down.
What ca1ore said is that he uses silicone labeled for aquarium use, as he does not want to spend time wading through tons of pages about silicone. Kind of like LED lighting. He had a bad experience, and so plays it safe just in case.
uncleof6, you seem to know a lot about silicone, and what you recommend seems to be very practical. If you respond, then the OP can take your advice and save a few $. If not, then the OP can buy silicone labeled for aquariums form petco. But the problem with taking advice about stuff like this is that there might be 10 silicones at Home Depot good for aquariums, and 5 that are not. But if you don't know how to tell the difference, then you risk losing more. Thus, it's a good idea to understand why you buy something rather than just take advice.
There aren't ten silicones at Home Depot suitable for use in aquariums. That is one of the greater problems with this. Home Depot is cheap, but you get what you pay for.
A great deal of this depends on the intended purpose, but we are dealing with a product that degrades over time when emersed in water (not just gets wet, but is emersed) Home Depot sells the bottom of the pile sealants. They do not carry commercial grade, or "adhesive silicones." Not that are 100% silicone, e.g. are not co-polymers with things like acrylic, at any rate. There is only one "aqaurium labeled" silicone that meets the requirements for an adhesive. I would be very interested in discovering what the product really is. But, because there are two suitable "adhesive silicones" already known, and in wide commercial use and readily available, there is really no reason to pursue the fact finding further.
One forgotten (for the most part) little factoid, is that GE Silicone I used to be labled by GE as "Aquarium Silicone." Due to a myriad of lawsuits from disgruntled customers whose tanks fell apart, catastrophically, the label was withdrawn, and the wording "not for aquarium use" was put on the label. It is interesting to note, unless it has been added, that RTV100 series silicones do not carry this warning, and neither does SCS1200 series--and the SCS1200 is the only one where the literature indicates that "successful aquarium applications have been accomplished." Go figure, because they turn right around and say not for use under water.
Silicone is a rather simple subject, that gets overly complicated, mostly due to myth and legend, and yes a great deal of opinion. The same information has been posted hundreds of times here on RC, by myself and others, and still there seems to be this big desire to debate the topic.
For the 35 years I have been involved in this hobby, the basic recommendations for silicone have never changed.
1-Part 100% Silicone (no co-polymers)
Acetoxy cure (silicone II is a neutral cure—the only difference from Silicone I)
FDA approved for food contact.
Suitable properties for the appliction. (added to further limit debate)
The tough part of this, is learning what which silicone is good for, and what it had better not be asked to do. There are literally thousands of silicones around. Many of them fit the bill above. Many more do not. To help with the chaos, a short list was devised. It is posted many times here on RC. It includes both Momentive and Dow Corning products. DAP and Aqueon are both included in that list. So also is GE Silicone I.
From an objective standpoint, based on physical properties alone, GE Silicone I sits at rock bottom basement junk, and excluding the one I mentioned above, RTV100 and SCS1200 are sitting on top of the pile, based solely on peel and tensile strength—as well as meeting the criteria above. The ones sitting on top cost LESS than silicones relabeled to "aquarium silicone," and can be used to build tanks—big tanks, the ones labeled aquarium silicones are consumer grade sealants (based on physical properties) and it is a bad idea to build tanks with them.
The problem is, you cannot get these products at home depot, and the places you could get them, were mostly put out of business by home depot. (that is a different story for a different venue

)
Which one to use, depends on the application. If you are sealing something, it really does not matter. You don't need the heavy hitters, but then why not, the price difference is negligible or less. If you are using it for structural purposes, you want something with more guts, hence the heavy hitters.
What is really frustrating, is tomorrow or the day after, someone will start a thread, post a picture of Silicone II and ask if it is reef safe. /: That is the net result of the need to continually debate this topic.
P.S. I am calm, been through this a hundred times....