some say once a week, some say after every use. i've waited two weeks once and saw all this black stuff when i flushed my spectrapure. now i do it for 30 seconds after every use.
the RO membrane is the most expensive part, if you can prolong its life with a $10 piece of plastic and tubing, do it.
rumor is units with GPD over 75 have lower contact time with the membrane hence more TDS, but i have no personal experience with it.