OK, more info. I ran a 150g for 2-3 years, no issues. Moved everything to a new 175 a month ago and at the same time (I know , I know), a purple and yellow tang came up at the same time from a club member who I have dealt with a for a long time came up. He needed to get them out fast for personal reasons.
Everything was fine for a week or so, and then the purple went down with what several folks said was ich. Not as bad as this though. The brown and a majestic also started having issues.
Started treating with ich attack as couldn't face tearing everything down to get the fish out, and my local buddies all agreed they could well just fight it off in time themselves anyway.... Interested in hearing comments on that one. Also bought a fire shrimp that fish were queuing up to be cleaned by the minute he went in the tank - sign of parasites?
3 day trip, left Monday morning before lights came on, back Weds night after lights out. Thursday at 2pm....oh sh*t.
Pulled the brown last night, dead this morning, but no surprise, he went down hill really fast which sucks as I have had him 2+ years, great fish,
Current livestock:
6" Majestic angel
Med. Yellow tang
Med. Purple tang
Skunk clown
12" Engineer goby
Black widow blenny
Falco hawk
Flame hawk
Flame tail blenny
Banggai
Prob another one I have missed
Two anemones
Multiple star fish
Fire shrimp might still be in there
So, suggestions on quarantine tank size? I also have a 40L with 2 Bangaiis and 2 clowns, and a 20L frag tank.
I am not sure I can face tearing everything down after building a dream tank/stand setup....

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Why do you say throw away the Ich Attack? What is Velvet?
Need to start reading up.
Thx for all the help. Much appreciated. (I feel like a freaking beginner after 11 years in the hobby)