I have a rather clever way of running my RO/DI system:
Install an in-line TDS meter, one probe after the membrane, and one probe after the first DI cartridge (if 2 are used like in my case) If your TDS leaving the membrane gets higher than 10-20, there's something wrong with membrane (good membranes let only about 2-10 TDS out where mine puts out 2) If your first DI cartridge reads anything above 0, replace it. But always make sure your membrane puts out as little TDS as possible (depending on quality of the membrane)
KEEP IN MIND:
Once the unit is turned on, your initial TDS readings on in-line meter will be really high (20-200) due to osmosis (where membrane stands by without being flushed), wait for 1-5 minutes to get accurate reading on in-line TDS meter.
Hope this helps! ask away if you need more info!