I have done it in the past with great success. It definitely does work. Several things to think about. Make sure you have a good skimmer running when dosing. Also, make sure you dose at a time so that you have your lights on for a few hours at least after dosing. Skimmer is essential for keeping O2 up and providing the primary basis of exporting excess bacteria. Lights also help to keep 02 up. Pay particular attention to cloudy water or any white slime build up. In either instance, you are having a bacterial bloom and need to reduce dosing until problems eleviate. Also, when and if you decide to eliminate dosing, do not abruptly stop dosing and gradually reduce dosing so as to allow your system to slowly rebalance. Otherwise, you may have a major cyno problem if you abruptly stop dosing.