indeed.
I have cut, heat formed, and "welded" (chemical welding with solvents) acrylic for art projects, tank furniture, and product displays....
I have never made a water tight tank, had access to laser or CNC equipment, or don'e anything large scale really...
As for "people who do it" (acrylic fabricating) in Albuquerque 2 names pop to mind: Southwest Acrylic Fabricators (located on Aztec and Princeton next to Piedmont Plastics) and Jule-Art, no idea where they are.... both have laser CNC equipment, and could probably make tanks but I know SW will not guarantee water tightness (or didn't a few years back when I talked to them).
They WILL custom cut any shape or pattern you could dream of and let you glue it up yourself. I may soon go that route if I don't find a decent 55g acrylic tank from CL soon.