IMHO there is no pleasant way to cull. For me keeping things in perspective is the most important thing.
Is letting newly hatched larvae get eaten or chopped up in pumps and power heads any different than culling/killing juvenile fish that don't measure up to breed standards? IDK
I think it is human nature to be more accepting of passive killing. In other words, the sight of nicely packaged meat/seafood at the grocery store does not violate most people's delicate sensibilities, but requires industrial scale killing which, if witnessed by the same consumers, would affect most of them deeply. If they had to participate, it would scar some of them for life. But even without our direct involvement, farm animals and wild caught food animals die because we(most of us anyway) eat them. I know ornamental fish don't seem to relate, but that grade A+ Picasso at the LFS required a lot of culling/killing.
I think the most interesting way I've ever heard it stated was a guy who told me "if you want to save a cow...eat a cheeseburger"
Bottom line for me is culling sucks. I hate it. it's my least favorite part of breedings clowns, but I hate not knowing if the WC specimens that I keep in my DT were responsibly harvested in a sustainable manner even more.
As for the best way to cull, I've already stated that I'm a chain of life...let something else eat them kind of guy, but if that option is not available then pithing is my preferred method. a little snip in just the right spot and it's over very quickly.