The bubbles in fresh water don't usually last long enough to give organics the time to diffuse to them and form a foam; so skimmers are largely ineffective at removing organics in freshwater.
The skimmer is especially useful in salt water when organic carbon, like: vodka, vinegar, etc., is dosed because:
it helps export the the extra organics including bacteria.;
running a skimmer also provides aeration to help CO2 and O2 levels that may be adversely effected by the extra bacterial activity.
So, if you:
aerate well by other means ,and ;
employ other effective organics removal techniques like granulated activated carbon and/or ozone;
organic carbon dosing could likely be used in a fresh water aquarium effectively.
I'm not aware of anyone using this technique in freshwater ; I'm not sure nitrate reduction ,a major aim of organic carbon dosing, is a significant concern in freshwater.