Depends on the purpose. For a single travel lens it's my 24-70. For portraits, it's the 85 /1.8. For [affordable] wildlife it's my 300 f/4 plus TC1.4. For landscapes it's either my 20 f/2.8 or my 24-70, unless I'm backpacking, then it's the 20 or 24. I sold my 70-200 VR 1 a year ago and don't miss it. It was just too heavy for carrying and for very long and too imposing for portrait work. In Africa on a research project, I carried an 80-400 for 5-7 hours a day for the zoom range, and would buy the new 80-400 for a similar trip. That's all Nikon gear. For occasional tank macros, I use my Tamron 90 f/2.8 macro. If I could only own one lens, it would be the 24-70 /2.8 - an amazing lens.